The Deeper Genome (Record no. 85411)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02211 am a2200193 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170523b xxu||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780199688746 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 574.87322 |
| Cutter | Par |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Parrington, John |
| 245 ## - TITLE STATEMENT | |
| Title | The Deeper Genome |
| Remainder of title | : Why there is more to the human genome than meets the eye |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc | 2015 |
| Name of publisher, distributor, etc | Oxford University Press |
| Place of publication, distribution, etc | Oxford |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | vii; 246p. |
| Other physical details | 8x5 |
| Dimensions | pb |
| 520 ## - Remark | |
| Summary, etc | Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined. |
| 546 ## - LANGUAGE NOTE | |
| Language note | ENG |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Human genome |
| Topical term or geographic name as entry element | Genomes |
| Topical term or geographic name as entry element | DNA |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Item type | Book |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Permanent location | Current location | Shelving location | Date acquired | Cost, normal purchase price | Full call number | Barcode | Date last seen | Date last borrowed | Cost, replacement price | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Book | HBCSE | HBCSE | General Science | 2017-05-26 | 760.75 | 574.87322/Par | 23943 | 2018-09-19 | 2017-10-25 | 895.00 | Book |