The First Three Decades of Gene Therapy: An Instant Update (Record no. 87386)
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| 000 -LEADER | |
|---|---|
| fixed length control field | nab a22 7a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230911161857.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230911b xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0002-7685 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | HBC |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 574.07/Hoh |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hoh, Yin Kiong |
| 245 ## - TITLE STATEMENT | |
| Title | The First Three Decades of Gene Therapy: An Instant Update |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Virginia: |
| Name of publisher, distributor, etc | National Association of Biology Teachers, |
| Date of publication, distribution, etc | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 17–22. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Gene therapy has fascinated clinicians, scientists, and patients since decades ago because of its potential to treat a disease at the genetic level. This can be achieved in many ways, including replacing a disease-causing gene with a healthy copy. Gene therapy must overcome complex tissue and cellular barriers to introduce genetic modifications into the nucleus of the target cells to drive a high level of gene expression. Moreover, the genetically corrected cells must be present in significantly large numbers in the body to reverse the diseased condition and yet able to escape immunological recognition and survive in the long term to sustain the benefit. This paper reviews the early work as well as recent developments in gene therapy, including improvements to viral vectors and novel treatment strategies, diseases targeted, approved gene therapies, and current challenges and prospects for future progress. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biology Education |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 80228 |
| Host Itemnumber | 82683 |
| Place, publisher, and date of publication | National Association of Biology Teachers California |
| Other item identifier | S2113 |
| Title | American Biology Teacher |
| International Standard Serial Number | 0002-7685 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBCSE | HBCSE | 2023-09-11 | 574.07/Hoh | ar3691 | 2023-09-11 | 2023-09-11 | Journal Article |