The current book is about learning the fundamental concepts in organic chemistry which is influenced by the Process Oriented Inquiry Learning (POGIL) approach. The chapters cover different core areas in organic chemistry and present a series of critical questions to learners, in an activity mode. By engaging in discussions with peers in a group, learners need to arrive at answers for the given series of questions. The authors of the book have field tested significant fractions of the written activity chapters with undergraduate students who have appreciated them. In such a setting, teachers play a challenging role of the facilitator and implement effective strategies to build an environment that assists fruitful learning in the groups. It is important that answers are not provided to learners by the instructors and no lectures are presented in such classes. The authors hope the guided inquiry learning approach used for writing the book presents enriching experiences to instructors and motivates them to implement such novel instructional approaches for their own classrooms.