000			nam a22 a 4500
999			_c69064 _d69064
008			140520s9999||||xx |||||||||||||| ||und||
020			_a0-521-80177-X
082			_a574.8851
082			_bDwy
100			_aDwyer, Rex
245			_aGenomic Perl : from bioinformatics basics to working code
260			_aCambridge
260			_bCambridge University Press
260			_c2003
300			_axvii;334
300			_bhb
300			_c7x10
350			_a1950
365			_b1755
440			_aBioinformatics
520			_aThis introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
942			_cBK